Today, on May 29, 2025, ISPOR - The Professional Society for Health Economics and Outcomes Research announced a new partnership with Tufts-CEVR to provide free, premium access to our Cost-Effectiveness Analysis (CEA) Registry for members who are students or who are researchers in government or academic institutions in a low- to middle-income country (LMIC). To help our new users jumpstart their use of the Registry, we’ve compiled a list of applications that can serve as a model for research.
Health Benefit Design
For researchers interested in health benefit package design, the CEA Registry can be used to inform efficient resource allocation.
- Simangolwa et al. used the CEA Registry and other sources for a systematic review of economic analyses conducted in Zambia to aid in benefits package design.
- Mohan et al. leveraged a statistical optimization approach to support the development of a health benefits package in Uganda.
- Connolly et al. used CEAs from the Registry to propose revisions to Malawi’s health benefits package.
Global Health, Policy, and Practice
Researchers can use the CEA Registry to identify and fill gaps in country-level, disease-level, or intervention-level literature.
- Silke et al. addressed the lack of country-specific CEAs in the paper “Cost-effectiveness of interventions for HIV/AIDS, malaria, syphilis, and tuberculosis in 128 countries: a meta-regression analysis”.
- Jiao et al. used the Registry to support their development of a health state utility catalog for sickle cell disease.
- Bejrananda et al. utilized the Registry to evaluate the cost-effectiveness of a new robotic-assisted surgical option for prostate cancer.
Novel Synthesis
The Registry can also be useful for estimating different forms of bias or nuance across CEAs.
- Xie et al. used the CEA Registry to examine potential bias in industry funding in cost-effectiveness results.
- Fox et al. measured indirect costs of Alzheimer's Disease and how their exclusion underestimates the total burden of the disease.
- Dunn et al. analyzed Registry data to answer the question “Are medical care prices still declining?”
- Students interested in evaluating cost-effectiveness analysis papers can use the CEA Registry data for a thesis or class project
Additional CEA Registry Applications
- Unique Applications of the CEA Registry in 2024
- 7th Annual Tufts-CEVR’s Cost-Effectiveness Paper of the Year Award Winners
- The death of QALYs is greatly exaggerated
About the CEA Registry
The Tufts-CEVR Cost-Effectiveness Analysis (CEA) Registry is a comprehensive database containing detailed information on over 14,000 cost-effectiveness analyses (CEA) that quantify health benefits in terms of quality-adjusted life-years (QALYs) or disability-adjusted life-years (DALYs). For each article, the Registry contains data on more than 50 variables related to the study’s methodology, CE ratios, and utility weights.
Since its creation in 1998, the CEA Registry has been cited or used in around 700 peer-reviewed articles. Topics range from cost-effectiveness analyses of specific interventions to health benefit package design to novel syntheses of economic data.
CEVR’s mission is to help decision makers identify society's best opportunities for targeting resources to improve health, assist policymakers in healthcare resource allocation decisions, and move the field towards the use of standard methodologies.
For more information, please visit https://cear.tuftsmedicalcenter.org/.